Brain Science Research

In addition to the general body of brain research, HAPPYneuron's scientific team in partnership with prestigious research institutions have studied the effectiveness of our brain training programs. Results to date show that HAPPYneuron programs can significantly improve memory, speed of processing, and provide a variety of cognitive benefits that positively impact quality of life. Research has also shown our programs may be effective in improving cognitive symptoms related to a number of different conditions.

1. Study	2009: Intensive Spatial Memory Training for older Adults
Size	40 subjects
Research Partners	University of Zurich, Institute of Psychology, Gerontopsychology
Investigator	Anne Eschen, Ph.D.
Status	In Progress

2. Study	2009: Neurocognitive Enhancement Therapy for Major Depressive Disorder
Size	40 subjects
Research Institution	Queen's University, Kingston, ON, Canada
Investigator	Christopher Bowie, Ph.D.
Status	In Progress

3. Study	2008-2009: Cognitive remediation effectiveness for schizophrenic patients
Investigators	Nicolas Franck, Institute for Cognitive Science, Lyon, France
Size	280 subjects, multi-site
Funded by	PHRC (French Government Funding Program for Clinical Research)
Status	In Progress
Presentation	9th World Congress of Biological Psychiatry, Paris, France, July 2009

4. Study	2008: Cognitive Training Improves Driving Skills
Investigators	Bernard Croisile, M.D., Ph.D., Reilhac, Ph.D., Bélier, Ph.D., Noir, Ph.D., Tarpin-Bernard, Ph.D.
Size	90 subjects
Status	Complete
Results	Subjects demonstrate an average of 14% improvement in key skills
Publication	Brain Training Influence on Cognitive Function Effectiveness at Boiron Labs

5. Study	2008: Benefits of Online Cognitive Training
Investigators	Bernard Croisile, M.D., Ph.D., Bélier, Ph.D., Noir, Ph.D., Tarpin-Bernard, Ph.D., Miner, M.A., M.S., Allain, Ph.D.
Size	217 subjects
Status	Complete
Results	Subjects demonstrate +8.5% average improvement
Publication	Pending

6. Study	2008: Cognitive rehabilitation for depressed patients
Size	30 subjects, 3 years
Research Partners	French National Science Research Center Paris 6 University at La Pitié-Salpêtriére Hospital
Investigator	Dr. Roland Jouvent
Status	In progress

7. Study	2007: Alzheimer's patients maintain cognitive skills and improve self confidence
Investigators	Dr. Foare, Sophia's Gardens, Alzheimer's disease clinic, Castelnau-le-Lez, France
Size	47 subjects
Status	Completed
Summary	Sophia's Gardens: AD patients maintain cognitive skills and improve self confidence

8. Study	2007: Cognitive rehabilitation of impaired patients
Research Institution	St. Anne Hospital in Paris, Psychiatric Department
Status	In Progress

9. Study	2007: Online Cognitive Training Improves Cognitive Performance
Investigators	Bernard Croisile, M.D., Ph.D., Bélier, Ph.D., Noir, Ph.D., Tarpin-Bernard, Ph.D., Allain, Ph.D.
Size	85 subjects
Status	Complete
Results	85 HAPPYneuron Users show +16% average improvement in 18 weeks
Publications	Online Cognitive Training Improves Cognitive Performance National Academy of Neuropyschology Poster American Society on Aging & National Council on Aging Conference Poster

10. Study	2007: Significant Brain Activity Improvement
Investigators	Robert Bender III, M.D., D.Michael
Funded by	The Center for Disease Control (CDC)
Status	Complete
Results	“Shows Significant Brain Activity Improvement. HAPPYneuron™ Games Key Component of Brain Wellness Program”
Publications	Effects of a Brain Wellness Program on Neuropsychological Testing and PET Scans CDC-Funded Pilot Study Shows Significant Brain Activity Improvement

11. Study	2006: MEMORY STIMULATION. WHICH SCIENTIFIC BENEFITS? WHICH EXERCISES?
Investigators	Bernard Croisile, M.D., Ph.D. et al
Size	39 subjects
Status	Complete
Results	HAPPYneuron Users show +12% average improvement in 18 weeks
Publication	Geriatrics Review' 2006;31:421-433 France

12. Study	2006-2008: Rehabilitation software program for schizophrenia patients
Research Institution	Lausanne Hospital, Switzerland
Investigators	Pascal Vianin, Ph.D.
Size	28 subjects
Funded by	CHUV (Centre Hospitalier Universitaire Vaudois)
Status	Complete
Presentation	Cognitive Remediation Conference, NYC, June 2009 - poster
Publication	Pending

13. Study	2003-2006: The Importance of Memory and Concentration Skills for Schoolchildren
Size	130 school children ages 10 and 11, over a 3 year time frame
Research Partners	City of Elancourt, France ; Association Initiatives Terrain, France ; Lille University, France
Investigator	Neukirch A., Fenouillet F., Hildebrandt R.
Status	Completed
Results	Better CMS score and various effects on recognition tasks.
Publications	Pending

14. Study	2001-2002: Transferability of Cognitive Training to every-day activities (AKA King 64)
Size	117 children, 10 years old
Research Partners	EMC laboratory (Université Lyon II — CNRS)
Investigator	Noir, Ph.D.
Status	Completed
Results	Average of 40%+ improvements in various cognitive skills performance
Publications	Thesis of M. Noir Ph. D (french)